Stability-indicating assay of secnidazole in the presence of its degradation products

Four new selective, precise and accurate first derivative spectrophotometric, RP-HPLC, TLC densitometric and colorimetric methods were described for the determination of secnidazole in the presence of its degradation products, 2-methyl-5-nitroimidazole and hydroxy propanol. These methods were suitable for stability testing of secnidazole in bulk powder retaining their accuracy in the presence of up to 70% and 90% of its degradation product. The proposed methods were applied for the analysis of pharmaceutical formulations and the recoveries were 99.40-100.52%. The results obtained agreed with the reported method

Spectrophotometric determination of fluoxetine and sertraline using chloranil2, 3 dichloro-5, 6 dicyanoquinone and iodine

Spectrophotometric procedures have been presented for the determination of 2 commonly used antidepressant drugs: Fluoxetine [I] and sertraline hydrochloride [II]. The methods have been based mainly on charge transfer complexation reaction of these drugs with either pi acceptors chloranil and 2, 3 dichloro-5, 6-dicyanoquinone [DDQ], or sigma acceptor iodine. The molar combining ratio and the optimum assay conditions were studied. More detailed investigation of the complex formed in chloranil method was made with respect to its composition, association constant Kc Ad, molar absorptivity epsilon lambda AD, and free energy change delta G. The proposed methods were applied successfully to the determination of the cited drugs either in pure or dosage forms with good accuracy and precision